The award recognizes ̽����Ƶ biochemist’s career dedication to the study of nucleosomes and groundbreaking discoveries

Karolin Luger, a distinguished professor of biochemistry and the Jennie Smoly Caruthers Endowed Chair of Biochemistry, has been awarded the .

The $100,000 award recognizes her career dedication to the study of nucleosomes—research that led to the groundbreaking capture of a high-resolution image of chromatin and resulted in the development of novel drug treatments for diseases including cancer.

The Vilcek Foundation Prizes in Biomedical Science honor immigrants who are leading advancements in biomedical research in the United States. Prize co-founder Jan Vilcek—whose research led to the development of the drug Remicade—established prizes to support distinct ingenuity in scientific inquiry.

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Karolin Luger, a distinguished professor of biochemistry and the Jennie Smoly Caruthers Endowed Chair of Biochemistry, has been awarded the . (Photo: Vilcek Foundation)

Presented annually since 2006, the Vilcek Foundation prizes honor immigrant contributions to societal advancement in the United States and recognize excellence in the arts and sciences. Since the prizes program began 20 years ago, the Vilcek Foundation has awarded $9.6 million to individuals “whose perspectives, creativity and vision have enriched the United States.”

“The Vilcek Foundation community are unwavering champions of the immigrants and leaders who advance every facet of our culture,” said Vilcek Foundation President Rick Kinsel. “The United States is a nation defined by freedom of expression, imagination and opportunity. This 20th group of prizewinners demonstrates our unshakeable commitment to honor those who embody the spirit of resiliency that defines our country and society.”

Luger, who is an investigator at the Howard Hughes Medical Institute, became interested in science at an early age, using a microscope to study the plants and soil in her garden at the microscopic level. She earned Bachelor and Master of Science degrees in biochemistry from the University of Innsbruck in Austria and a PhD in biochemistry and biophysics from the University of Basel in Switzerland before immigrating to the United States in 1990.

“I came (to the United States) to join this amazing scientific enterprise that is the envy of the entire world,” Luger said.

As an immigrant from Austria who has participated in international research collaborations throughout her career, Luger notes that cross-cultural perspectives are essential to continued scientific advancement.

“Diversity is key because everything becomes clearer and more three-dimensional when illuminated from all sides,” said Luger. “To borrow a concept from structural biology: You need to see ‘all orientations!’ This can only be achieved with a diverse workforce where people constantly question each other’s assumptions.”

‘The central dogma’

In her postdoctoral studies at ETH Zürich in Switzerland, Luger focused on the atomic structure of nucleosomes, the discovery of which would help scientists understand fundamental aspects of the human genome. After eight years of research, Luger and her colleague, Tim Richmond at ETH Zürich, published a groundbreaking paper that has influenced innumerable studies and changed how researchers understand the interactions of proteins within the nucleosome, how proteins are modified and how this controls gene activity.

Since its publication 28 years ago, the paper has been cited more than 12,000 times and is included in biology textbooks and classes as part of “the central dogma.”

Because of Luger’s discovery, many diseases have since been found to stem from mutations in the nucleosome, resulting in the development of successful drug treatments. Luger continues to study nucleosomes in her laboratory work.

“Like many others, my lab has built on this original discovery, and we continue to be surprised by the elegant and complicated ways in which DNA access is regulated by nucleosomes,” Luger said. “I am proud to have contributed a bit of beauty and knowledge to the world.”

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